Endocrine Abstracts

Adaptation of oxidative metabolism is essential for meeting different energy demands in different tissues, or altered energy demands in response to stressors, such as exposure to cold. The orphan nuclear receptor ERRα (estrogen-related receptor alpha) is implicated in the regulation of energy metabolism. ERRα expression is high in tissues with high oxidative capacity and increased at physiologic states of increased energy demand. Moreover, ERRα activity and expr...